Estudios científicos

Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis

Abstract:

OBJECTIVES: The purpose of this study was to quantify the relation between alcohol consumption and cardiovascular and total mortality in patients with a history of cardiovascular events. BACKGROUND: Regular, moderate alcohol consumption by healthy people is associated with lower cardiovascular and all-cause mortality. No extensive meta-analysis is presently available on the possible association of alcohol consumption with secondary events in patients with cardiovascular disease. METHODS: Articles were retrieved through October 2009 by search in PubMed and EMBASE. Fifty-four publications were identified, but only 8 were selected for our analyses, including 16,351 patients with a history of cardiovascular disease. Secondary events were cardiovascular or all-cause mortality. All selected studies were prospective. Data were pooled with a weighted, least-squares regression analysis of second-order fractional polynomial models. RESULTS: The meta-analysis on cardiovascular mortality showed a J-shaped pooled curve with a significant maximal protection (average 22%) by alcohol at approximately 26 g/day. In the meta-analysis on mortality for any cause, J-shaped pooled curves were observed in the overall analysis (average maximal protection of 18% in the range of 5 to 10 g/day) and in all subgroups according to either the type of patients or the characteristics of the studies. CONCLUSIONS: In patients with cardiovascular disease, light to moderate alcohol consumption (5 to 25 g/day) was significantly associated with a lower incidence of cardiovascular and all-cause mortality.

Comentarios divulgativos:

Pocos estudios están en este momento disponibles que hayan examinado la asociación entre el consumo de bebidas alcohólicas y acontecimientos coronarios en pacientes con enfermedades cardiovasculares. Una Investigación realizada por la Universidad Católica de Campobasso, Italia, sugiere que el consumo de vino moderado no sólo previene la enfermedad coronaria en la gente sana. Este meta-análisis incluyó ocho estudios previos con un total de 16,351 pacientes que ya habían sido afectados por un acontecimiento isquémico y que fueron rastreados durante ocho años. Los autores concluyeron que el consumo regular moderado de bebidas alcohólicas (5-25g/día) tiene efectos beneficiosos para los que ya han experimentado un infarto.No sólo eran pacientes con menos probabilidades de ser afectados por enfermedades similares, su riesgo en todo-causa también se redujo en la mortalidad (independientemente de la causa de muerte).