Estudios científicos
Alcohol consumption and probable rapid eye movement sleep behavior disorder
Abstract:
OBJECTIVE:
To systematically examine the association between alcohol intake and likelihood of having probable rapid eye movement sleep behavior disorder (pRBD) 6 years later.
METHODS:
The study included 11,905 participants (mean age: 47.7 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury in 2006. We determined pRBD using a validated RBD questionnaire-Hong Kong in 2012. Amounts and types of alcohol intake were collected with questionnaire. Participants were categorized into: nondrinkers, light (women: 0-0.4 servings/day; men: 0-0.9 servings/day), moderate (women: 0.5-1.0 servings/day; men: 1-2 servings/day), and heavy drinkers(women: >1 serving/day; men: >2 servings/day). To examine the alcohol-pRBD relationship, we used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic characteristics, smoking, hypertension, diabetes, physical activity, body mass index, and plasma concentrations of lipids and urate.
RESULTS:
Compared with nondrinkers, current drinkers had a 23% higher likelihood of having pRBD (adjusted OR 1.23, 95% CI 1.07-1.59). Both moderate (adjusted OR: 1.53, 95% CI 1.01-2.30) and heavy drinkers (adjusted OR: 1.29, 95% CI 1.00-1.66), but not light drinkers (adjusted OR: 1.16, 95% CI 0.94-1.44), had a significantly higher likelihood of having pRBD, relative to nondrinkers. There was a nonsignificant trend between consumption of each individual alcoholic beverages (i.e., beer, wine, or hard liquor) and higher likelihood of having pRBD (adjusted ORs ranged from 1.11 to 1.49).
CONCLUSIONS:
Alcohol consumption was associated with a higher likelihood of having pRBD. Future prospective studies with clinically confirmed RBD, large sample size for information on types of alcoholic beverage are warranted.
Comentarios divulgativos:
Este estudio trata de determinar si existe relación entre el consumo de alcohol y la probabilidad de tener un trastorno conductual del sueño de movimiento rápido del globo ocular. Para ello se incluyeron en el estudio a 11.905 adultos sanos, que se agruparon según su consumo de alcohol en no bebedores, consumo bajo (mujeres 0-0,4 ración/día, hombres 0-0,9 raciones/día), moderado (mujeres 0,5-1,0 ración/día, hombres 1-2 raciones/día) o alto (mujeres >1 ración/día, hombres >2 raciones/día). Y cumplimentaron un cuestionario validado para el diagnóstico de este trastorno. Se realizó un seguimiento de 6 años.
Los resultados obtenidos indicaron que los bebedores tenían un 23% más de riesgo de desarrollar este tipo de trastornos, frente a los no bebedores. Cuando se analizaba el riesgo por grupos, sólo un consumo moderado y alto de bebidas alcohólicas se relacionaba con un mayor riesgo. Asimismo, cuando se evaluaba el incremento de riesgo debido al consumo de un tipo concreto de bebida no se observaban asociaciones significativas. Por lo tanto, el consumo de alcohol parece estar asociado con un mayor riesgo de trastorno conductual del sueño de movimiento rápido del globo ocular, por lo que es necesario seguir investigando en este sentido.
