Estudios científicos

Anti-atherogenic effects of resveratrol


Resveratrol (RS), a polyphenol compound found in grapes and grape products, including wine, peanuts and berries, exists in cis- and trans-isomeric forms. RS is believed to decrease circulating low-density lipoprotein cholesterol levels and reduce cardiovascular disease (CVD) risk. However, it is possible that RS has other mechanisms to reduce the risk of CVD without altering lipid levels. The objective of this review is to critically examine results from recent research concerning potential effects of RS on CVD. RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates alpha-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD.European Journal of Clinical Nutrition advance online publication, 19 May 2010; doi:10.1038/ejcn.2010.77.

Comentarios divulgativos:

El resveratrol es un polifenol el cual se encuentra en uvas y sus productos derivados incluyendo el vino tinto. Este compuesto existe en su forma cis y trans. Se cree que disminuye la baja circulación de las lipoproteínas del colesterol y reduce el riesgo de enfermedades cardiovasculares. Sin embargo es posible que el resveratrol tenga otros mecanismos para disminuir el riesgo de enfermedades coronarias sin alterar los niveles de lípidos. El objetivo de este estudio es hacer una revisión crítica sobre los últimos hallazgos del efecto del reveratrol sobre el riesgo de padecer enfermedades cardiovasculares.