Estudios científicos

Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation


Neuroinflammation is an important contributor to pathogenesis of neurological disorders, with microglial activation as a hallmark of neuroinflammation. Microglia serve the role of immune surveillance under normal conditions, but after brain damage or exposure to inflammation, microglia are activated and secrete pro-inflammatory and neurotoxic mediators. Sustained production of these factors contributes to neuronal damage. Therefore, inhibition of microglia-mediated neuroinflammation may become a promising therapeutic target for neurological disorders. Resveratrol, a non-flavonoid polyphenol rich in red wine and grapes, has beneficial health effects from its antioxidant, anticancer and anti-inflammatory properties. Recently, resveratrol has been shown to protect against various neurological disorders in experimental models, including brain ischemia, seizures, and neurodegenerative disease models. This minireview summarized the anti-inflammatory activities of resveratrol in the brain from both in vivo and in vitro studies, and highlighted the inhibition of activated microglia as a potential mechanism of neuroprotection. The release of various pro-inflammatory factors, the production of reactive oxygen species, and the activation of signal pathways leading to neuroinflammation were discussed in relation to microglial activation. Taken together, microglia are an important target for anti-inflammatory activities of resveratrol in the brain. (c) 2010 Elsevier B.V. All rights reserved.


Comentarios divulgativos:

La neuroinflamación es un importante efecto de los defectos neuronales, la activación de la microglía sirve como marcador de la neuroinflamación. Después de ocurrir un daño cerebral la microglía es activada y segrega compuestos proinflamatorios y neurotóxicos. Por lo tanto, una inhibición en la microglía puede ser una prometedora diana terapeutica para los desordenes neuronales. El resveratrol compuesto de presente en el vino tinto y uvas tiene efectos beneficiosos por sus propiedades antioxidantes, anticancerigenas y antinflamatorias.