Estudios científicos

Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation

Abstract:

Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a polyphenol found in the skin of the grape and red wine, has been found to have chemopreventitive effects in some carcinogenic models. The effects of resveratrol on the initiation of Barrett's metaplasia and the carcinogenic progression to esophageal adenocarcinoma have not been evaluated. The aim of this study was to evaluate the effects of resveratrol on the transition from reflux esophagitis to Barrett's metaplasia to dysplasia to esophageal adenocarcinoma in an established rat model. Male Sprague-Dawley rats underwent esophagoduodenal anastomosis as per institutional approved protocol. They were then treated twice weekly with intraperitoneal injection of 7 mg/kg of resveratrol or saline. Additional nonoperated rats served as controls. The rats in each group were assigned to 1, 3, or 5-month subgroups. The distal esophagus was preserved for blinded histopathological examination at the time of harvest. Thirty-one animals in the 5-month resveratrol group showed a decreased severity of esophagitis (P<0.0001), incidence of intestinal metaplasia (P = 0.3567), and incidence of carcinoma (P = 0.4590) as compared with both the saline and nonoperated control groups. In conclusion, morphological characteristics consistent with decreased esophagitis and incidences of metaplasia and esophageal adenocarcinoma were seen on histopathology in the resveratrol group. Resveratrol resulted in a small diminution of the carcinogenic effects and progression to metaplasia, and further human studies are designed to explore the potential anticarcinogenic mechanism.

Comentarios divulgativos:

El resveratrol (3,5,4-trihydroxy-trans-stilbeno) es un polifenol que se encuentra en la piel de las uvas y en el vino tinto.Se ha visto que este compuesto tiene efectos quimiopreventivos en algunos modelos carcinogenéticos. Los efectos del resveratrol en la iniciación de la metaplasia de Barrett y de la progresión carcinogénica del adenocarcinoma esofágico no han sido evaluados. El objetivo de este estudio es evaluarlos efectos del resveratrol en la transición del reflujo esofaguítico de la metaplasma de Barett a la displasia del adenocarcinoma esofageal en un modelo establecido en ratas. En el grupo estudio con resveratrol mediante histopatología se observó una disminución de caracteristicas morfológicas como la esofaguitos y metaplasma. El resveratrol dió una pequeña disminución de los efectos carcinogénicos y de la progresión de la metaplasia