Coffee and wine consumption is associated with reduced mortality from alcoholic liver disease: follow-up of 219,279 Norwegian men and women aged 30-67 years
To study the association between coffee and alcoholic beverage consumption and alcoholic liver disease mortality.
In total, 219,279 men and women aged 30-67 years attended cardiovascular screening in Norway from 1994 to 2003. Linkage to the Cause of Death Registry identified 93 deaths from alcoholic liver disease. Coffee consumption was categorized into four levels: 0, 1-4, 5-8, and greater than or equal to 9 cups/d and alcohol consumption as 0, greater than 0 to less than 1.0, 1.0 to less than 2.0, and greater than or equal to 2.0 units/d, for beer, wine, liquor, and total alcohol consumption.
The hazard ratios per one category of consumption were 2.06 (95% confidence interval 1.62-2.61), 0.68 (0.46-1.00), and 2.54 (1.92-3.36) for beer, wine, and liquor, respectively. Stratification at 5 cups/d (the mean) revealed a stronger association between alcohol consumption and alcoholic liver disease at less than 5 versus 5 or more cups/d. With less than 5 cups/d, 0 alcohol units/d as reference, the hazard ratio reached to 25.5 (9.2-70.5) for greater than or equal to 2 units/d, whereas with greater than or equal to 5 cups/d, it reached 5.8 (1.9-17.9) for greater than or equal to 2 units/d. A test for interaction was significant (P = .01).
Coffee and wine consumption were inversely associated with alcoholic liver disease death. Total alcohol consumption was adversely associated with alcoholic liver disease mortality and the strength of the association varied with the level of coffee consumption.
En este estudio los autores se plantean si existe algún tipo de asociación entre el consumo y la mortalidad por enfermedad hepática alcohólica.
Para ello recogieron datos de 219.279 personas noruegas de 30-67 años entre 1994-2003, que habían acudido a la unidad de cardiología. Y observaron que existía una relación adversa entre el consumo y la mortalidad por enfermedad hepática alcohólica. Sin embargo, ingestas más elevadas de café parecían tener una menor relación con la mortalidad por cirrosis hepática, mientras que el vino se asociaba inversamente con la mortalidad por enfermedad hepática alcohólica.