Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine
BACKGROUND: Red wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and flow rate. METHODS: Twenty-two healthy men consumed a high dose (8.1+/-0.9dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and flow rate assessed using transthoracic echocardiography before and acutely after intervention. RESULTS: Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75+/-0.26pg/mL to 0.61+/-0.20pg/mL, p=0.002; 0.74+/-0.32pg/mL to 0.63+/-0.24pg/mL, p=0.04, respectively), but did not have a significant effect on epicardial diameter (1.1+/-0.3mm vs. 1.1+/-0.3mm, p=0.58; and 1.1+/-0.3mm vs. 1.1+/-0.2mm, p=0.10, respectively) or flow rate (7.8+/-4.0mL/min to 6.4+/-3.6mL/min, p=0.07; and 7.8+/-4.0mL/min to 7.4+/-3.2mL/min, p=0.53, respectively). CONCLUSIONS: Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or flow rate.
En este estudio versa sobre los efectos de la consumición de vino tinto en el comportamiento de la proteína endotelina-1 comparándolo con los efectos sobre el diámetro de la arteria epicardica y el ratio de flujo sanguíneo. El vino tinto y el desalcoholizado vino tinto disminuyen los niveles de endotelina 1 pero este cambio no se ve reflejado en los niveles de diámetro y de flujo sanguíneo.