Estudios científicos
Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine
Abstract:
BACKGROUND: Red wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and flow rate. METHODS: Twenty-two healthy men consumed a high dose (8.1+/-0.9dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and flow rate assessed using transthoracic echocardiography before and acutely after intervention. RESULTS: Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75+/-0.26pg/mL to 0.61+/-0.20pg/mL, p=0.002; 0.74+/-0.32pg/mL to 0.63+/-0.24pg/mL, p=0.04, respectively), but did not have a significant effect on epicardial diameter (1.1+/-0.3mm vs. 1.1+/-0.3mm, p=0.58; and 1.1+/-0.3mm vs. 1.1+/-0.2mm, p=0.10, respectively) or flow rate (7.8+/-4.0mL/min to 6.4+/-3.6mL/min, p=0.07; and 7.8+/-4.0mL/min to 7.4+/-3.2mL/min, p=0.53, respectively). CONCLUSIONS: Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or flow rate.
Comentarios divulgativos:
En este estudio versa sobre los efectos de la consumición de vino tinto en el comportamiento de la proteína endotelina-1 comparándolo con los efectos sobre el diámetro de la arteria epicardica y el ratio de flujo sanguíneo. El vino tinto y el desalcoholizado vino tinto disminuyen los niveles de endotelina 1 pero este cambio no se ve reflejado en los niveles de diámetro y de flujo sanguíneo.
