Estudios científicos
Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation.
Abstract:
The effects of the phenolic compounds catechin (Cat), quercetin (Qer), and resveratrol (Res) present in red wine on early atherosclerosis were studied in hamsters. Hamsters (n = 32) were divided into 4 groups of 8 and fed an atherogenic diet for 12 weeks. They received by force-feeding 7.14 mL/(kg of body wt.day) Cat, Qer, or Res in water [2.856 mg/(kg of body wt.day) for Cat and 0.1428 mg/(kg of body wt.dday) for Qer and Res], mimicking a moderate consumption of alcohol-free red wine (equivalent to that supplied by the consumption of about two glasses of red wine per meal for a 70 kg human), or water as control. Plasma cholesterol concentration was lower in groups that consumed phenolics than in controls. The increase in plasma apolipoprotein (Apo) A1 concentration was mainly due to Cat (26%) and Qer (22%) and to a lesser extent, but nonsignificantly, Res (19%). Apo-B was not affected. Plasma antioxidant capacity was not improved, and there was no sparing effect on plasma vitamins A and E. Plasma iron and copper concentrations were not modified nor were liver super oxide dismutase and catalase activities. A sparing effect of Qer on liver glutathione peroxidase activity appeared, whereas Cat and Res exhibited a smaller effect. Aortic fatty streak area was significantly reduced in the groups receiving Cat (84%) or Qer (80%) or Res (76%) in comparison with the controls. These findings demonstrate that catechin, quercetin, and resveratrol at nutritional doses prevent the development of atherosclerosis through several indirect mechanisms.
Comentarios divulgativos:
Los efectos de la catequina, la quercetina (Jer.), y el resveratrol (Res) presentes en el vino tinto fueron estudiados en hámsters con aterosclerosis temprana. Hamsters (n = 32) fueron divididos en 4 grupos de 8 y alimentados con una dieta aterogénica durante 12 semanas. Ellos recibieron por alimentación forzada 7,14 ml / (kg de wt.day cuerpo) Caterpillar, Jer., o Res en agua [2.856 mg / (kg de wt.day cuerpo) para Cat y 0,1428 mg / (kg de peso corporal wt.dday ) para Jer. y] Res, imitando a un consumo moderado de vino tinto sin alcohol (equivalente a la suministrada por el consumo de alrededor de dos vasos de vino tinto por comida para un humano de 70 kg), o agua como control. La concentración plasmática de colesterol fue menor en mujeres que consumieron fenólicos que en los controles. El aumento de la apolipoproteína plasma (Apo) A1 se debió principalmente a cat (26%) y Jer. (22%) y en menor medida, pero no significativa, Res. (19%). Apo-B no se vio afectada.su capacidad antioxidante del plasma no mejoró, y no hubo efecto ahorrador en plasma para las vitaminas A y E. Las concentraciones plasmáticas de hierro y el cobre no se modificaron para la superóxido dismutasa y catalasa. Un efecto ahorrador de Jer. sobre la actividad glutatión peroxidasa hepática apareció, mientras que cat mostró un efecto menor. Estos hallazgos demuestran que la catequina, quercetina y resveratrol en dosis nutricionales previenen el desarrollo de la aterosclerosis a través de varios mecanismos indirectos.
