Estudios científicos
Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension
Abstract:
Physical inactivity during space flight or prolonged bed rest causes rapid and marked loss of bone mass in humans. Resveratrol, a red wine polyphenol that is currently under study for its therapeutic antioxidant properties, has been shown to significantly modulate biomarkers of bone metabolism, i.e., to promote osteoblast differentiation and to prevent bone loss induced by estrogen deficiency. However, there is no direct evidence supporting its inhibitory effect toward bone loss during physical inactivity. In the present study, effects of resveratrol on bone mineral density (BMD), bone mineral content, and bone structure were examined in the femora and tibiae of tail-suspended and unsuspended rats using X-ray micro-computed tomography (micro-CT). Rats were treated with 400 mg/kg/day of resveratrol for 45 days and half of them were suspended during the last 2 weeks of treatment. Suspension caused a decrease in tibial and femoral BMD and deterioration of trabecular and cortical bone. Bone deterioration during suspension was paralleled by increased bone marrow area, which could be caused by an increase in stromal cells with osteoclastogenic potential or in adipocytes. Resveratrol had a preventive effect against bone loss induced by hindlimb immobilization. In particular, trabecular bone in the proximal tibial metaphysis was totally preserved in rats treated with resveratrol before tail-suspension.
Comentarios divulgativos:
La inactividad física durante tiempos prolongados de vuelo o estancias prolongadas en reposo causan una rápida pérdida de la masa ósea. El resveratrol y los polifenoles del vino tinto están siendo estudiados por sus propiedades antioxidantes, además han mostrado que son moduladores del metabolismo óseo promoviendo la diferenciación de los osteoblastos y previniendo la pérdida de peso inducida por una deficiencia en estrógeno.
En este estudio se estudian los efectos del resveratrol en la densidad mineral de los huesos, contenido mineral de los huesos y estructura ósea. Se concluye que el resveratrol tiene un efecto preventivo contra la pérdida de hueso inducida por la inmovilización.
