Estudios científicos
Effect of Resveratrol, a Dietary-Derived Polyphenol, on the Oxidative Stress and Polyol Pathway in the Lens of Rats with Streptozotocin-Induced Diabetes
Abstract:
Resveratrol is found in grapes, apples, blueberries, mulberries, peanuts, pistachios, plums and red wine. Resveratrol has been shown to possess antioxidative activity and a variety of preventive effects in models of many diseases. The aim of the study was to investigate if this substance may counteract the oxidative stress and polyol pathway in the lens of diabetic rats. The study was conducted on the rats with streptozotocin-induced type 1 diabetes. After the administration of resveratrol (10 and 20 mg/kg po for 4 weeks), the oxidative stress markers in the lens were evaluated: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, calcium, sulfhydryl group, advanced oxidation protein products, malonyldialdehyde, Total Oxidant Status and Total Antioxidant Reactivity. The obtained results indicate that the administration of resveratrol to the diabetic rats shows antioxidative properties. It is not a result of antiglycaemic activity but resveratrol probably directly affects the antioxidative system. Resveratrol did not affect the polyol pathway in the lens of diabetic rats. Our results may indirectly indicate benefits of consumption of foods as well as dietary supplements containing resveratrol in diminishing oxidative stress in lenses of individuals suffering from diabetes mellitus.
Comentarios divulgativos:
El resveratrol se ha relacionado con un efecto antioxidante y mejoras en modelos animales de numerosas enfermedades.
En este estudio los autores tratan de valorar si la suplementación con resveratrol de la dieta de ratas diabéticas puede afectar al estrés oxidativo y a la vía del polialcohol contrarrestando el efecto de la enfermedad sobre el cristalino.
Para ello se administró a las ratas 10 o 20 mg de resveratrol por kg de peso durante 4 semanas. Los resultados obtenidos indicaron un efecto antioxidante del resveratrol, pero sin diferencias en la glucemia. Y tampoco se modificó la vía de los polialcoholes en los cristalinos. De manera que la suplementación con resveratrol podría ser útil en la reducción del estrés oxidativo a nivel de cristalino en las ratas diabéticas.
