Estudios científicos
Exacerbation of tobacco smoke mediated apoptosis by resveratrol: An unexpected consequence of its antioxidant action
Abstract:
Resveratrol, a polyphenolic compound rich in grapes and red wine, has been reported to protect cells against oxidative damage and cell death by increasing cellular antioxidant/detoxification capacity. Cigarette smoking is a major risk factor for respiratory diseases and oxidative damage is implicated in its pathogenesis. Here we investigated the enhancement of antioxidant capacity by resveratrol and its potential protection against cell death caused by cigarette smoke in human bronchial epithelial cells (HBE1). At concentrations that did not affect cell growth, resveratrol activated Nrf2 signaling and increased the expression of NAD(P)H:quinone reductase-1, heme oxygenase-1, and the catalytic subunit of glutamate cysteine ligase. Surprisingly, instead of protecting against cell death, resveratrol significantly enhanced cigarette smoke extract-induced apoptosis. To define the underlying mechanism, the effect of resveratrol on caspase activity was examined and it was found that resveratrol significantly enhanced cigarette smoke-stimulated caspase activity. In conclusion, results from this study suggest that although resveratrol increased antioxidant and detoxification capacity, it increased rather than protected against cigarette smoke-induced apoptosis. Copyright © 2010 Elsevier Ltd. All rights reserved.
Comentarios divulgativos:
El resveratrol es un compuesto polifenólico rico en uvas y vino tinto el cual ha sido mostrado como protector celular contra el daño oxidativo y la muerte celular debido a sus capacidades antioxidantes y detoxificantes. El tabaquismo es un factor de alto riesgo para padecer enfermedades respiratorias y daño oxidativo implicado en diferentes patogénesis. En este estudio se investiga la capacidad antioxidante del resveratrol y su potencial protección frente al daño celular causado por el tabaco en las células epiteliales de los bronquios. En conclusión, los resultados de este estudio sugieren que aunque el resveratrol incrementa la capacidad antioxidante y detoxificante este incremento induce apoptosis.
