Estudios científicos
Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model.
Abstract:
Among therapeutic approaches that have been investigated, targeting of receptors implicated in managing neuroinflammation has been described. One such family of receptors comprises the formyl peptide receptors (FPRs) whose ligands could play a role in host defense. The murine FPR gene family includes at least six members while in humans there are only three. The two most important members are the Fpr1 and Fpr2. Fpr1encodes murine FPR1, which is considered the murine orthologue of human FPR. Resveratrol, a non-flavonoid polyphenol rich in red wine and grapes, apart from its beneficial health effects and anti-inflammatory properties, has been reported to reduce neuroinflammation in different neurodegenerative disease models. Resveratrol anti-inflammatory responses involve the activation of the protein deacetylase sirtuin 1 (SIRT1) gene. In this work we have investigated in an LPS-based murine model of neuroinflammation the role of FPR1, examining not only if this receptor undergoes a reduction of its expression during neuroinflammation, but also whether treatment with resveratrol was able to modulate its expression leading to an amelioration of neuroinflammatory picture in a murine model of neuroinflammation. Results of this work showed that FPR1 together with SIRT1 resulted upregulated by resveratrol treatment and that this increase is associated with an amelioration of the neuroinflammatory picture, as demonstrated by the induction of IL-10 and IL1-RA expression and the downregulation of proinflammatory mediators, such as TNF-α and IL-1β. The expression and the modulation of FPR1 by resveratrol may be evaluated in order to propose a novel anti-inflammatory and pro-resolving therapeutic approach for the reduction of the detrimental effects associated with neuro-inflammation based neurodegenerative diseases and also as a promising strategy to promote human health by a diet rich in antioxidative bioactive compounds.
Comentarios divulgativos:
La neuroinflamación es una respuesta inflamatoria dentro del cerebro o la médula espinal. Una de las proteínas implicadas en el manejo de la neuroinflamación son los receptores de formil péptidos acoplados a proteínas G, presentes en las células inmunitarias. El resveratrol es un polifenol no flavonoide, presente en el vino y en las uvas, que se ha relacionado con efectos beneficiosos para la salud incluidas propiedades neuroprotectoras y efectos antiinflamatorios. Este trabajo investiga en un modelo de ratón con neuroinflamación, el efecto del tratamiento con resveratrol en la expresión y modulación del receptor peptídico formil 1.
Los resultados mostraron que el resveratrol regulaba la expresión del receptor peptídico formil 1 y reducía los signos típicos de la neuroinflamación, al disminuir las moléculas proinflamatorias y estimular las antiinflamatorias. Indicando que el resveratrol podría ser un candidato prometedor en el desarrollo de tratamientos frente a la neuroinflamación. No obstante, son necesarios más estudios que permitan conocer en detalle su funcionamiento.
