Estudios científicos
Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy.
Abstract:
Recent studies suggest that moderate red wine consumption may confer several health benefits, including protection against heart disease, certain cancers and multiple age-related neurological diseases such as Alzheimer's disease. These health benefits are assumed to come from a compound from grape skin called resveratrol, which has been proposed to be a pro-longevity agent. Whether resveratrol accounts for all the health benefits of grape-derived nutrients and the molecular and cellular mechanisms underlying the beneficial effects of such nutrients are not well understood. Here we investigated the effect of supplementing grape skin extract (GSE) left from red wine-production process to the daily food intake of a Drosophila melanogaster model of Parkinson's disease (PD) associated with PTEN-induced kinase 1 (PINK1) loss-of-function. Consumption of GSE resulted in rescue of mitochondrial morphological defects, improvement of indirect flight muscle function and health-span, and prolonged lifespan of the PINK1 mutant flies. Further biochemical and genetic studies revealed a link between activation of mitophagy and the beneficial effects of GSE. Our results indicate that GSE can promote autophagy activation, preserve mitochondria function, and protect against PD pathogenesis, and that the beneficial effect of GSE in mitophagy activation is not accounted for by resveratrol alone.
Comentarios divulgativos:
El hollejo de la uva tinta es un material rico en compuestos con propiedades antioxidantes como la proantocianidina y la quercetina y en polifenoles como el resveratrol. Éste compuesto se ha relacionado con la prevención del desarrollo de la enfermedad de Párkinson, a través de la inhibición de la formación de placas β- amiloides.
En este estudio los investigadores utilizan un modelo animal de Párkinson (Drosophila PINK1) para estudiar si la suplementación oral con un extracto de hollejo puede mejorar los efectos perjudiciales de la disfunción mitocondrial que socia la enfermedad.
Los resultados obtenidos mostraron un efecto positivo de las suplementación, relacionado con mejoras a nivel mitocondrial y muscular, la activación de la mitofagia y con un incremento de esperanza de vida.
