Bidirectional and mediation Mendelian randomization of dietary intake and risks of gastric ulcer and gastric cancer

Epidemiological studies have suggested associations between dietary intake and gastric ulcer (GU) or gastric cancer (GC), but the causal relationships remain unclear. This study aimed to clarify these links using…

Mediterranean Alcohol-Drinking Pattern and Alcohol-Related Cancer Incidence in the «Seguimiento Universidad de Navarra» (SUN) Cohort

ackground/Objectives: Since 1988, the IARC has classified alcohol as a type 1 carcinogen, causally linked to seven types of cancer (oral cavity, pharynx, larynx, esophagus, colorectum, liver and breast carcinomas).…

Impact of Alcohol Intake on Parkinson’s Disease Risk and Progression: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

The association between alcohol consumption and Parkinson’s disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta-analyzed 16 studies (2014-2024)…

Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts

Background and aims: The benefits of the Mediterranean diet (MedDiet) are well established. However, one component, wine, remains controversial. This study assessed the association between MedDiet (with or without wine consumption)…

Red wine (poly)phenols supplementation reduces amyloid-beta (aβ) pathology in APP/PS1 mice model: Possible implications of gut-brain axis explored by untargeted fecal metabolomics

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder influenced by genetics and lifestyle. The Mediterranean diet, especially moderate red wine (RW) intake, may offer neuroprotection through (poly)phenols acting on amyloid…

Alcohol, health and cardiovascular disease.

Recent epidemiological studies have shown that alcohol consumption can increase the risk of arterial hypertension, atrial fibrillation and gastrointestinal and breast cancer. Various sectors are therefore promoting abstinence from alcohol.…

Red Wine Extract Prevents Oxidative Stress and Inflammation in ARPE-19 Retinal Cells

Age-related macular degeneration (AMD) is one of the most commonly occurring ocular diseases worldwide. This degenerative condition affects the retina and leads to the loss of central vision. The current…

Resveratrol inhibits autophagy against myocardial ischemia- reperfusion injury through the DJ-1/MEKK1/JNK pathway.

Resveratrol (RES), a natural polyphenolic compound found in red wine and grape skins, has attracted significant attention due to its cardioprotective properties. DJ-1, a multifunctional protein that participated in transcription…

Red Wine High-Molecular-Weight Polyphenolic Complex Ameliorates High-Fat Diet-Induced Metabolic Dysregulation and Perturbation in Gut Microbiota in Mice.

Red wine polyphenolic complexes have attracted increasing attention as potential modulators of human metabolic disease risk. Our previous study discovered that red wine high-molecular-weight polymeric polyphenolic complexes (HPPCs) could inhibit…