Estudios científicos

Piceatannol, a metabolite of resveratrol, attenuates atopic dermatitis by targeting Janus kinase 1

Abstract:

Background: Piceatannol is a resveratrol metabolite commonly found in red wine, grapes. Several studies have investigated the immune-modulating effects of piceatannol on processes related to allergic reactions. However, the relationship between piceatannol and atopic dermatitis (AD) has not yet been reported. This study sought to investigate the effects of piceatannol in animal and cell line models.

Methods: AD-like symptoms and skin lesions were triggered by repeated topical treatment of Dermatophagoides farinae extract (DFE) on the skin of NC/Nga mice. The molecular mechanism of piceatannol was studied in the TNFα/IFNγ-induced HaCaT cell line.

Results: Piceatannol attenuated DFE-induced AD-like symptoms, as shown by skin thickness, dermatitis score, scratching time, and skin water loss. Histopathological analysis showed that piceatannol suppressed DFE-induced immune cell infiltration into the skin. These results occurred concomitantly with the downregulation of inflammatory markers, including serum and skin TARC and MDC. Piceatannol decreased phosphorylation of JAK-STAT protein in the TNFα/IFNγ-induced HaCaT cell line. A molecular docking study showed that piceatannol strongly interacts with JAK1, suggesting a possible mode of action.

Conclusion: The study results showed that piceatannol, a metabolite of resveratrol, attenuates atopic dermatitis and provide important implication of development of piceatannol as functional ingredients or therapeutic agents.

Comentarios divulgativos:

El picetanol es un metabolito derivado del resveratrol, un compuesto que ha mostrado tener propiedades beneficiosas, que se obtiene principalmente a partir del vino tinto. El picetanol ha mostrado efectos positivos moduladores del sistema inmunitario, y en este estudio se evalúa su efecto en la mejora de la dermatitis atópica. Los resultados en modelos animales y celulares fueron positivos, indicando que el picetanol atenúa los síntomas de la dermatitis (grado de engrosamiento de la piel, puntuación de dermatitis, rascado y deshidratación de la piel), al suprimir la infiltración de células del sistema inmunitario en la piel y reducir los marcadores de inflamación.