Estudios científicos
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies
Abstract:
Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study, we summarize and discuss the neuroprotective effects of polydatin in CNS disorders and related pathological conditions in preclinical animal studies. A systematic review was performed by searching online databases, returning a total of 110 records, where 27 articles were selected and discussed here. The included studies showed neuroprotective effects of polydatin in experimental models of neurological disorders, including cerebrovascular disorders, Parkinson’s disease, traumatic brain injuries, diabetic neuropathy, glioblastoma, and neurotoxicity induced by chemical agents. Most studies were focused on stroke (22.2%) and conducted in male rodents. The intervention protocol with polydatin was mainly acute (66.7%), with postdamage induction treatment being the most commonly used regimen (55.2%). Overall, polydatin ameliorated behavioral dysfunctions and/or promoted neurological function by virtue of its antioxidant and antiinflammatory properties. In summary, this review offers important scientific evidence for the neuroprotective effects and distinct pharmacological mechanisms of polydatin that not only enhances the present understanding but is also useful for the development of future preclinical and clinical investigations.
Comentarios divulgativos:
El piceído o polidatina es un fitoquímico de grupo de los estilbenos, que al igual que el resveratrol, se encuentra en las uvas, los cacahuetes y el vino tinto. Esta revisión sistemática recoge los últimos avances sobre el efecto protector de este compuesto en la salud del sistema nervioso central, que está basada principalmente en resultados de 27 estudios en modelos animales.
La polidatina con propiedades antioxidantes y antiinflamatorias, parece reducir el daño y las secuelas. Las investigaciones realizadas hasta el momento han evaluado su efecto en el ictus, pero también en trastornos neurológicos, enfermedad de Párkinson, lesiones por traumatismo, neuropatía diabética, glioblastomas y neurotoxicidad por químicos. Este compuesto podría ser útil en el desarrollo de nuevas estrategias farmacológicas.
