Estudios científicos

Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis.


This experimental study investigated the prophylactic effects of the antioxidant and antiaggregant compound resveratrol (R) on portal vein thrombosis (PVT) in rats. Thirty rats weighing 200- 250 g were distributed in 3 groups: Group A (n = 10) and underwent PVT+R, Group B (n = 10) PVT alone, and Group C (n = 10) were subjected to a sham operation. Group A rats received R (60 mg/d per naso-gastric tube) for 10 days before PVT. Concerning antioxidant status, statistically significant increases in both tissue and plasma levels of reduced glutathione (GSH) and decrease in malondialdehyde (MDA) levels were observed in the PVT+R group compared with the PVT group (P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue and plasma levels of GSH and low MDA levels among the sham-operated group when compared with to the PVT+R or PVT groups (P < .001 for all). Concerning the antiaggregant status, significant increases of c-AMP levels were detected in rats treated with R before experiencing PVT (P < .001). Cyclic AMP levels in the sham group were significantly higher than those of either the PVT or PVT+R groups (P < .001). One may advise patients undergoing liver transplantation and carrying certain cardiovascular disease risk factors to ingest foods containing R to minimize PVT.

Comentarios divulgativos:

Este estudio experimental que investigó los efectos profilácticos de compuestos antioxidantes y antiagregantes como el resveratrol (R) en la trombosis venosa en ratas(PVT). Treinta ratas de peso de 200 a 250 g se distribuyeron en 3 grupos: Grupo A (n = 10) y se sometió a PVT + I, Grupo B (n = 10) PVT solo, y Grupo C (n = 10) fueron sometidos a una operación simulada. En cuanto al estado de antiagregantes, los aumentos significativos de los niveles de c-AMP fueron detectados en las ratas tratadas con R antes de su experimentación. Los niveles de AMP cíclico en el grupo simulado fueron significativamente más altos que los de cualquiera. Por tanto se puede recomendar a los pacientes sometidos a trasplante hepático y con ciertos factores de riesgo cardiovascular ingerir alimentos que contengan R para minimizar la PVT.