Protective effects of resveratrol on small intestines against intestinal ischemia-reperfusion injury in rats
• J Gastroenterol Hepatol. 2009 Nov;24(11):1703-5.
BACKGROUND AND AIM: The aim of this study was to determine whether resveratrol could prevent intestinal tissue injury induced by ischemia-reperfusion (I/R). METHODS: Intestinal I/R was induced in rats' intestines by 60-min occlusion of the superior mesenteric artery, followed by a 60-min reperfusion. Thirty rats were divided into three groups as follows: sham (group 1), control (group 2), and the treatment groups (group 3). The rats in the treatment group received resveratrol both before ischemia and before reperfusion. In all groups, serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels were determined. Total antioxidant capacity (TAC), catalase, total oxidative status (TOS), oxidative stress index (OSI), and myeloperoxidase (MPO) in the intestinal tissue were measured. Intestinal tissue histopathology was also evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 were significantly lower than those in group 2 (P < 0.05). TAC in the intestinal tissue was significantly higher in group 3 than in group 2 (P < 0.05). TOS, OSI, and MPO in the intestinal tissue were significantly lower in group 3 than in group 2 (P < 0.05 for all). Histological tissue damage was milder in the resveratrol treatment group than in the control group. CONCLUSIONS: The results of this study indicated that resveratrol treatment limits the oxidative injury of the small intestine induced by I/R in rats. However, more precise investigations are required to evaluate the antioxidative effect of resveratrol on small intestine tissue damage in clinical and experimental models.
El objeto de este estudio es determinar como el resveratrol puede prevenir el daño celular intestinal producido por la repercusión isquémica (I/R). Para ello se induce la repercusión isquémica en intestinos de ratas ocluyendo 60 minutos la arteria mesenterica superior seguida de una repercusión de 60 minutos. Se dividieron 30 ratas en tres grupos: placebo, control y grupo de tratamiento. Las ratas que recibieron tratamiento recibieron resveratrol antes de la isquemia y después de la repercusión.
Los resultados de este estudio indican que el tratamiento con resveratrol limita el daño oxidativo del intestino inducido por I/R en ratas. Sin embargo se necesitan más estudios para evaluar los efectos antioxidantes del resveratrol.
The results of this study indicated that resveratrol treatment limits the oxidative injury of the small intestine induced by I/R in rats. However, more precise investigations are required to evaluate the antioxidative effect of resveratrol on small intestine tissue damage in clinical and experimental models.