Estudios científicos
Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis.
Abstract:
Recent studies have shown that resveratrol (3,5,4'-trihydroxystilbene), a polyphenolic compound found in grapes and red wine, has various beneficial effects on cardiovascular diseases and prolongs the life span of mice fed a high-fat diet. We hypothesized that resveratrol may attenuate vascular inflammatory response induced by angiotensin (Ang) II. We examined the effect of resveratrol on Ang II-induced interleukin (IL)-6 expression in vascular smooth muscle cells (VSMCs). Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol.
Comentarios divulgativos:
Recientes estudios muestran que el resveratrol, un polifenol presente en uvas y en vino tinto tiene efectos beneficiosos contra las enfermedades cardiovasculares y frolonga el ciclo de vida en ratones alimentados con una dieta rica en grasas. Estos investigadores proponen la hipótesis de que el rsveratrol puede atenuar la rspuesta inflamatoria inducida por la Angiotensina II (ang II). En este estudio se examina el efecto del resveratrol en las células vasculares (VSMCs) con Ang II induciendo la expresión de interleukina (IL) 6. El resveratrol atenua significativamente de una manera dosis-dependiente el efecto de AngII induciendo la expresión del mRNA IL-6 y la expresión de la proteína IL-6 en el sobrenadante de células VSMC. Estos datos sugieren que la inflamación vascular y la presión arterial alta que provoca la AngII son inhibidas por el resveratrol al menos en parte.
