Estudios científicos

Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines

Abstract:

Resveratrol, which is highly concentrated in the skin of grapes and is abundant in red wine, has been demonstrated to account for several beneficial properties, including antioxidant, anticoagulant, anti-inflammatory and anticancer effects. Taxol is a microtubule-stabilizing drug that has been extensively used as effective chemotherapeutic agents in the treatment of solid tumors. Here, we investigated whether the combination of the two compounds would yield increased antitumor efficacy in human cancer cells. Unexpectedly, resveratrol effectively prevented tumor cell death induced by taxol in 5637 bladder cancer cells. This pronounced antagonistic function of resveratrol against taxol was associated with changes in multiple signal transduction pathways, but not with tubulin polymerization. Importantly, cell cycle analysis showed that resveratrol prevented the cells from entering into mitosis, the phase in which taxol exerts its action. Furthermore, resveratrol blocked the cytotoxic effects of vinblastine but not cisplatin in 5637 cells. Interestingly, resveratrol pre-treatment followed by taxol resulted in synergistic cytotoxicity. Finally, we extended our studies to various human cancer cell lines. Taken together, our results indicate that resveratrol may have the potential to negate the therapeutic efficacy of taxol and suggest that consumption of resveratrol-related products may be contraindicated during cancer therapy with taxol.

Comentarios divulgativos:

El resveratrol es un compuesto altamente concentrado en la piel de las uvas y es muy abundante en el vino tinto. Se ha demostrado que posee múltiple propiedades beneficiosas como propiedades antioxidantes, anticoagulantes, antinflamatoria y anticancerígeno. El taxol es una droga que estabiliza los microtúbulos y se usa como tratamiento de tumores. En este estudio se investiga sobre la combinación de estos componentes para comprobar si la combinación de ambos incrementa su eficacia antimtumorogénica. De gran importancia es el hallazgo de que pretratamientos con resveratrol seguidos de una ingesta de taxol mostraron un efecto de citotoxicidad. Los resultados indican que el resveratrol tiene el potencial de anular los efectos del taxol , por tanto estos resultados sugieren que el consumo de resveratrol puede estar contraindicado durante la terapia anticancerígeno con taxol.