Estudios científicos

Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1


Epidemiological and experimental reports have linked mild-to-moderate wine and/or grape consumption to a lowered incidence of cardiovascular, cerebrovascular, and peripheral vascular risk. This study revealed that resveratrol, an enriched bioactive polyphenol in red wine, selectively induces heme oxygenase 1 (HO1) in a dose- and time-dependent manner in cultured mouse cortical neuronal cells and provides neuroprotection from free-radical or excitotoxicity damage. This protection was lost when cells were treated with a protein synthesis or heme oxygenase inhibitor, suggesting that HO1 induction is at least partially required for resveratrol's prophylactic properties. Furthermore, resveratrol pretreatment dose-dependently protected mice subjected to an optimized ischemic-reperfusion stroke model. Mice in which HO1 was selectively deleted lost most, if not all, of the beneficial effects. Together, the data suggest a potential intracellular pathway by which resveratrol can provide cell/organ resistance against neuropathological conditions. Copyright 2010 Elsevier Inc. All rights reserved.

Comentarios divulgativos:

Datos experimentales y epidemiológicos han mostrado que una moderada consumición de vino tinto o uvas disminuyes la incidencia de padecer enfermedades cardiovasculares, cerebrovasculares y riesgos vasculares. Este estudio muestra como el resveratrol induce la hemoxigenasa 1 de una manera dependiente de dosis y tiempo en células en cultivo de neuronas corticales de ratón y promueve neuroprotección frente al daño neuropatológico.
Los resultados sugieren una potencial ruta intercelular en la cual el resveratrol de resistencia contra condiciones neuropatológicas