Estudios científicos

Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats


PURPOSE: Resveratrol, a polyphenolic compound mainly abundant in red wines, has beneficial cardiovascular effects on various pathological conditions. However, at present, the effect of resveratrol on health promotion remains unclear. Therefore, in this study, we assessed whether long-term resveratrol supplementation changes endothelial function, vascular contractility, nitric oxide and superoxide production in healthy male and female rats. METHODS: Wistar rats were treated with resveratrol (50 mg/l) in their drinking water for 3 weeks. We investigated relaxation to acetylcholine (10(-9)-10(-4) M) and contractions to phenylephrine (10(-9)-3 x 10(-4) M) and angiotensin II (10(-10)-10(-5) M) in either endothelium-intact or denuded aortae from control and resveratrol-treated male and female rats. Aortic superoxide production capacity was measured in response to provocation by angiotensin II and NAD(P)H. Plasma nitrite/nitrate levels and superoxide dismutase (SOD) activity were also evaluated. RESULTS: Resveratrol supplementation gender independently increased relaxation to acetylcholine and decreased contractions to phenylephrine and angiotensin II in endothelium-intact aortic rings, but not in endothelium-denuded arteries, from healthy male and female rats. This was associated with increased plasma nitrite/nitrate levels. Furthermore, resveratrol caused a refractoriness to angiotensin II and NAD(P)H-induced provocation in superoxide production. CONCLUSION: Our results suggest that resveratrol supplementation gender independently could improve the capacity of endothelial function and suppression of oxidative stress under physiological conditions. Resveratrol ingestion indicates a potential for cardiovascular health promotion.

Comentarios divulgativos:

El resveratrol es un compuesto polifenolico abundante en vino tinto con efectos cardiovasculares beneficiosos. Sin embargo el efecto del resveratrol en la promoción de la salud es todavia desconocido. En este estudio se investigan como la suplentación en la dieta cambia la función endotelial, la contracción vascular así como la producción de oxido nitrico y superoxido en ratas machos y hembras sanas.
Los resultados suguieren que la suplementación en la dieta con resveratrol puede mejorar la capacidad de la función endotelial y la supresión del estres oxidativo bajo condiciones fisiológicas. Por tanto el resveratrol puede ser un compuesto potencial en la mejora de la protección cardiaca.