Estudios científicos
Resveratrol's Potential in the Adjunctive Management of Cardiovascular Disease, Obesity, Diabetes, Alzheimer Disease, and Cancer
Abstract:
Resveratrol is a naturally occurring polyphenol that can be found in several human dietary sources, including red wine; many plants, especially grapes, berries, and nuts; and nutritional supplements. Findings from numerous preclinical experiments and clinical trials in humans suggest that resveratrol may play an important role in managing or preventing a variety of diseases. Some of the health benefits include cardioprotective effects; chemopreventive properties; metabolic changes, such as improved glycemic control; protection from diabetic consequences; and synergistic therapeutic effects when administered with other treatment modalities. Resveratrol has been found to be safe and reasonably well tolerated in humans, with mild to moderate gastrointestinal side effects. This review provides a summary of recent preclinical experiments and clinical trials pertaining to the effects of resveratrol on cardiovascular disease, obesity, diabetes, Alzheimer disease, and cancer. It also identifies suggested mechanisms by which resveratrol functions and presents issues surrounding resveratrol concentrations in vitro vs plasma levels reported in vivo.
Comentarios divulgativos:
El resveratrol es un polifenol que se ha relacionado con un efecto beneficioso para la salud. Sus concentraciones son especialmente elevadas en alimentos como en el vino tinto, las uvas, frutos rojos y frutos secos, así como en suplementos nutricionales. Se trata de una molécula segura y con una tolerancia buena, asociándose con trastornos gastrointestinales leves o moderados. Y se relaciona con efectos quimiopreventivos, a nivel metabólico con la mejora del control glucémico y también se han observado sinergias en el caso de algunos tratamientos. En ensayos clínicos y preclínicos se relaciona con mejoras en enfermedades cardiovasculares, diabetes tipo 2, obesidad, enfermedad de Alzheimer o cáncer.
