The relationship between alcohol consumption and vascular complications and mortality in individuals with type 2 diabetes melltius
OBJECTIVE: Moderate alcohol consumption has been associated with a reduced risk of mortality and coronary artery disease. The relationship between cardiovascular health and alcohol use in type 2 diabetes is less clear. The current study assesses the effects of alcohol use among participants in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.
RESEARCH DESIGN AND METHODS: The effects of alcohol use were explored using Cox regression models, adjusted for potential confounders. The study end points were cardiovascular events (cardiovascular death, myocardial infarction, and stroke), microvascular complications (new or worsening nephropathy or retinopathy), and all-cause mortality.
RESULTS: During a median of 5 years of follow-up, 1,031 (9%) patients died, 1,147 (10%) experienced a cardiovascular event, and 1,136 (10%) experienced a microvascular complication. Compared with patients who reported no alcohol consumption, those who reported moderate consumption had fewer cardiovascular events (adjusted hazard ratio [aHR] 0.83; 95% CI 0.72-0.95; P = 0.008), less microvascular complications (aHR 0.85; 95% CI 0.73-0.99; P = 0.03), and lower all-cause mortality (aHR 0.87; 96% CI 0.75-1.00; P = 0.05). The benefits were particularly evident in participants who drank predominantly wine (cardiovascular events aHR 0.78, 95% CI 0.63-0.95, P = 0.01; all-cause mortality aHR 0.77, 95% CI 0.62-0.95, P = 0.02). Compared with patients who reported no alcohol consumption, those who reported heavy consumption had dose-dependent higher risks of cardiovascular events and all-cause mortality.
CONCLUSIONS: In patients with type 2 diabetes, moderate alcohol use, particularly wine consumption, is associated with reduced risks of cardiovascular events and all-cause mortality.
El consumo moderado de vino en pacientes con diabetes tipo 2 se asocia con un menor riesgo de eventos cardiovasculares, también reduciendo la mortalidad por cualquier causa. La relación entre la salud cardiovascular y el consumo de alcohol en la diabetes tipo 2 ha sido históricamente menos clara. El presente estudio evalúa los efectos del consumo de alcohol entre pacientes con diabetes tipo 2. Los investigadores encontraron que durante el estudio, los pacientes que consumían principalmente vino obtuvieron mayores beneficios que aquellos que no; tuvieron menos eventos cardiovasculares, incluida la muerte cardiovascular, infarto de miocardio y accidente cerebrovascular.
Moderate wine consumption in patients with type 2 diabetes is associated with a lower risk of cardiovascular events, also reducing mortality from any cause. The relationship between cardiovascular health and alcohol use in type 2 diabetes has historically been unclear. This study evaluates the effects of alcohol consumption among patients with type 2 diabetes. The researchers found that during the study, patients who mainly consumed wine obtained great benefits than those who did not: they had fewer cardiovascular events, including cardiovascular death, myocardial infarction and stroke.