Estudios científicos

Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk

Abstract:

BACKGROUND AND AIMS: Dietary factors are critical for the prevention and treatment of hypertension, but data on the effects of specific nutrients on blood pressure (BP) are scarce. The aim of this study was to assess the relationship between total polyphenol excretion (TPE) in urine, as an objective measurement of total polyphenol intake and BP in an elderly population at high cardiovascular risk. METHODS AND RESULTS: Cross-sectional substudy of 589 high-risk participants entering in the PREDIMED trial. BP was measured and TPE was determined in urine by Folin-Ciocalteu assay. A significant positive association was observed between TPE in urine and daily intake of fruit and vegetables (F&V), coffee or wine after adjusting for potential confounders. The intake of 100g of F&V (Beta=0.150;P<0.001) had a greater contribution to TPE than 100mL of coffee (Beta=0.141;P=0.001), and the latter two foods contributed more than the consumption of 100mL of wine (Beta=0.120;P=0.019). An inverse association was observed between urinary TPE and the prevalence of hypertension. Participants in the highest quartile of urinary TPE had a reduced prevalence of hypertension compared to those in the lowest quartile (Odds Ratio=0.64; 95% confidence interval 0.45 to 0.92; P=0.015). Systolic and diastolic BP were inversely associated with urinary TPE after adjustment for potential confounders (P=0.024 and P=0.003, respectively). CONCLUSIONS: Polyphenol intake, assessed via TPE in urine, was negatively associated with BP levels and prevalence of hypertension in an elderly Mediterranean population at high cardiovascular risk. Participants with the highest intake of polyphenol-rich foods showed the lowest BP measurements. Copyright © 2009 Elsevier B.V. All rights reserved.

Comentarios divulgativos:

Los Factores dietéticos son esenciales en la prevención y tratamiento de la hipertensión, Pero los datos sobre los efectos de determinados nutrientes sobre la presión arterial (PA) son muy escasas. El objetivo de este estudio fue evaluar la relación entre la excreción total de polifenoles (TPE) en la orina, como una medición objetiva de la ingesta total de polifenoles en una población de ancianos de alto riesgo cardiovascular. Se realizó un subestudio transversal de 589 participantes de alto riesgo y se midió el TPE en la orina mediante un ensayo de Folin-Ciocalteu. Se observó una asociación positiva significativa entre el TPE en la orina y la ingesta diaria de frutas y hortalizas (F & V), café y vino. Se observó una asociación invertida entre la prevalencia urinaria del TPE en la hipertensión. La ingesta de polifenoles se evaluó a través del TPE en la orina y se asoció negativamente con los niveles de PA y la prevalencia de la hipertensión en una población mediterránea de alto riesgo cardiovascular en ancianos. Los Participantes con la m,ayor ingesta de alimentos ricos en polifenoles mostraron una menor medida de la PA.