Estudios científicos
Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans
Abstract:
Wine and alcohol consumption has been considered to be protective against coronary heart disease development, an oxidative stress associated disease. Wine contains polyphenols displaying antioxidant properties tested in in vitro and in vivo studies. Due to this, a general consensus exists, both among the general public and the scientific community, that wine, particularly red wine, is an antioxidant beverage. Alcohol consumption, however, is associated with oxidative damage. Several studies have been carried out on the antioxidant health benefits of wine and wine polyphenols. However, adequate scientific evidence (Level I or II) is required to be provided before recommendations or statements which can reach the general public can be formulated. Here, we summarize the state of the art of the up-to-date body of knowledge, and the extent to which there exists evidence of the benefits of moderate wine consumption on oxidative damage in humans. From the available data, there is no evidence, at present, that sustained wine consumption provides antioxidant benefits in healthy volunteers other than to counteract a possible pro-oxidative effect of the alcohol. On the contrary, data on the antioxidant protective effect of red wine in oxidative stress situations are promising. In this way, the postprandial oxidative stress after a meal, despite the diversity of biomarkers used for its evaluation, is counteracted by the ingestion of wine. Further studies are warranted. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Comentarios divulgativos:
La consumición de vino y alcohol han sido consideradas como protectoras contra enfermedades coronarias y enfermedades relacionadas con el estrés oxidativo. El vino, especialmente el vino tinto contiene polifenoles para los cuales ha sido probado tanto in vivo como in vitro poseen efectos antioxidantes. Debido a esta razón especialmente el vino tinto es una bebida antioxidante, sin embargo el alcohol está asociado con daño oxidativo. En este estudio se recogen los datos disponibles sobre los beneficios de una consumición moderada de vino. Según los datos disponibles no existe una evidencia hasta el momento de que la consumición de vino provea de beneficios antioxidantes en voluntarios sanos sin embargo los datos sobre el posible efecto protector del vino tinto en estrés oxidativo son prometedores.
