Estudios científicos

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure.


BACKGROUND AND AIMS: Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD. We investigated whether consuming resveratrol, a polyphenol found in red wine, can enhance FMD acutely and whether there is a dose-response relationship for this effect. METHODS AND RESULTS: 19 overweight/obese (BMI 25-35 kg m(-2)) men or post-menopausal women with untreated borderline hypertension (systolic BP: 130-160 mmHg or diastolic BP: 85-100 mmHg) consumed three doses of resveratrol (resVida 30, 90 and 270 mg) and a placebo at weekly intervals in a double-blind, randomized crossover comparison. One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration (P < 0.01). CONCLUSION: Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.

Comentarios divulgativos:

La dilatación mediada por el flujo de la arteria braquial (FMD) es un biomarcador de la función endotelial y de la salud cardiovascular. El deterioro de la FMD se asocia con varios factores de riesgo cardiovasculares incluyendo la hipertensión y la obesidad. Varios componentes como son los polifenoles presentes en diversos alimentos han demostrado mejorar la FMD. Se investigó si el consumo de resveratrol, un polifenol presente en el vino tinto, puede aumentar FMD de forma aguda y si existe una relación dosis-respuesta para este efecto. Para ello 19 hombreso o mujeres posmenopáusicas con sobrepeso u obesos (BMI 25-35 kg m (-2) consumieron tres dosis de resveratrol y un placebo a intervalos semanales. Una hora después del consumo del suplemento se midió el resveratrol presente en plasma y la FMD. Hubo un efecto significativo de dosis de resveratrol en la concentración plasmática del resveratrol y sobre la FMD. El consumo agudo de resveratrol aumenta las concentraciones plasmáticas de resveratrol y la FMD de manera dosis-dependiente. Este efecto puede contribuir a la salud sobre beneficios cardiovasculares.