Estudios científicos

Resveratrol: a multifunctional compound improving endothelial function. Editorial to:

Abstract:

The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.

Comentarios divulgativos:

El resveratrol presente el el vino tinto muestra actividades implicadas en la relajación endotelial. Estas propiedades son relacionadas con el oxido nítrico producido por la NO sintasa.Otros efectos del resveratrol están mediados mediante la regulación de SIRT1 o del receptor del estrógeno.